Neutralising Antibodies – Communicable Diseases Research

Immunogenicity and safety of BNT162b2 mRNA vaccine in Chinese adults: A phase 2 randomised clinical trial

Article

Published on 2022-12-012022-10-06
Journal: The Lancet Regional Health - Western Pacific
[Category] 진단,

Antibody correlates of protection from SARS-CoV-2 reinfection prior to vaccination: A nested case-control within the SIREN study

Article

Published on 2022-11-012022-11-15
Journal: The Journal of Infection
[Category] SARS, 진단, 치료기술,

Humoral response and neutralising capacity at 6 months post-vaccination against COVID-19 among institutionalised older adults in Argentina

Article

Published on 2022-09-262022-11-15
Journal: Frontiers in Immunology
[Category] SARS, 진단,

[키워드] affected age aging adults Anti-spike anti-Spike IgG antibody AZD1222 B.1 BBIBP-CorV Buenos Aires Cohort Complete correlation COVID-19 COVID-19 pandemic death different time point dose elicited evaluated Evidence evidenced exhibited Gender highlighting hospitalisation humoral Humoral response IgG titer IgG titers initial management neutralising Neutralising activity Neutralising Antibodies neutralising antibodies. Older omicron pandemic participant Participants plasma sample platform provide public health resulting SARS-CoV-2 significantly higher Sputnik-V Strong vaccination vaccination schedule vaccine platform Volunteer
[DOI] 10.3389/fimmu.2022.992370 PMC 바로가기

SARS-CoV-2 Omicron BA.5: Evolving tropism and evasion of potent humoral responses and resistance to clinical immunotherapeutics relative to viral variants of concern

Article

Published on 2022-09-182022-10-06
Journal: EBioMedicine
[Category] COVID19(2023년), SARS, 변종, 진단, 치료제,

[키워드] absence ACE2 acute respiratory syndrome ADK antibody BA.2 BA.5 Beta BNT162b2 breadth Breakthrough infection cell line change circulating clade Clinical effect cohorts contributed convalescent convalescent sera coronavirus COVID-19 COVID-19 hospitalisation Delta development disease severity Donor donors dose foundation Future genetic difference greater humoral Humoral response IgG in vitro isolate Lineage lineages Live virus management monitoring monoclonal antibody mortality rates nafamostat nasopharyngeal sample nasopharyngeal swabs neutralisation neutralisation assay Neutralising Antibodies neutralising antibody New observation of BNT162b2 omicron Omicron BA.1 other variant pathway peak plasma potency recorded reduced reduction reduction in Research response responses SARS-CoV-2 sensitivity significantly Sotrovimab South Spread Support supported tested Testing therapeutic Therapies TMPRSS2 TMPRSS2 inhibitor TMPRSS2. Transmission utilised vaccination Vaccine variant viral lineage viral variant
[DOI] 10.1016/j.ebiom.2022.104270 PMC 바로가기 [Article Type] Article

Improved Neutralisation of the SARS-CoV-2 Omicron Variant following a Booster Dose of Pfizer-BioNTech (BNT162b2) COVID-19 Vaccine

Article

Published on 2022-09-132022-11-15
Journal: Viruses
[Category] SARS, 변종, 진단,

Immune Determinants of Viral Clearance in Hospitalised COVID-19 Patients: Reduced Circulating Naïve CD4+ T Cell Counts Correspond with Delayed Viral Clearance

Article

Published on 2022-09-022022-11-15
Journal: Cells
[Category] SARS, 진단,

Different humoral but similar cellular responses of patients with autoimmune inflammatory rheumatic diseases under disease-modifying antirheumatic drugs after COVID-19 vaccination

Article

Published on 2022-09-012022-11-15
Journal: RMD Open
[Category] SARS, 진단,

[키워드] activated Activation antibody Autoimmune Autoimmune diseases Cellular immune response cellular response Combination correlated COVID-19 COVID-19 vaccination csDMARD cytokine cytokine profile drug drugs evaluated female first vaccination Frequency Heterologous highest humoral IgG immunosuppressive immunosuppressive therapy Inflammatory inhibitor investigated majority marker median age medications methotrexate monotherapy mRNA-based vaccine MTX Neutralising Antibodies neutralising antibody no difference not significant outcome Patient psoriatic arthritis quantification receiving rheumatic disease rheumatoid arthritis SARS-CoV-2 second vaccination Seroconversion spike-protein spondyloarthritis T-cell T-cell immunity T-lymphocyte T-lymphocyte subsets Therapies therapy titre treated vaccination vaccination.
[DOI] 10.1136/rmdopen-2022-002293 PMC 바로가기

A platform technology for generating subunit vaccines against diverse viral pathogens

Article

Published on 2022-08-182022-11-15
Journal: Frontiers in Immunology
[Category] 진단,

[키워드] acting affinity tag animal model Antigen binding can be used Clamp conformation COVID-19 pandemic Ebola virus elicit epitope fusion fusion protein glycoprotein immune response immunologically Infectious disease MERS-CoV Microscopy middle molecular monoclonal antibody mRNA neutralising Neutralising Antibodies Nipah virus offer platform precursor prefusion purification reagent remained respiratory syndrome coronavirus shown size exclusion chromatography stability stimulated Streamline subunit Subunit vaccine subunit vaccines tested trimeric Vaccine vaccine candidate vaccine platform Viral antigen viral challenge viral pathogen viral. virus virus
[DOI] 10.3389/fimmu.2022.963023 PMC 바로가기

Skin-patch delivered subunit vaccine induces broadly neutralising antibodies against SARS-CoV-2 variants of concern

피부 패치 전달 소단위 백신은 우려되는 SARS-CoV-2 변이체에 대한 광범위 중화 항체 유도

Article

Published on 2022-08-122022-09-11
Journal: Vaccine
[Category] COVID19(2023년), MERS, SARS, 변종, 진단,

Structural basis of Omicron immune evasion: A comparative computational study

오미크론 면역 회피의 구조적 기반: 비교 전산 연구

Article

Published on 2022-08-012022-09-11
Journal: Computers in biology and medicine
[Category] COVID19(2023년), SARS, 변종,

[키워드] ACE2 Affect analysis angiotensin antibody binding affinities binding affinity Compromised Compromised neutralisation Critical Delta develop effective Effectiveness Efficacy evaluated explain immune Immune escape immune evasion immunogenic interact Interaction interface mapped molecular docking molecular dynamics Molecular dynamics simulation molecular dynamics simulations Mutation neutralisation Neutralising Antibodies neutralising antibody new strain omicron Omicron variant Protein RBD Receptor binding domain receptors reported robust S protein SARS-CoV-2 SARS-CoV-2 variants SARS-CoV-2 variants. several variants Spike protein the antibody the binding affinity the spike protein Vaccine Vaccine design variant variants variants of concern virus
[DOI] 10.1016/j.compbiomed.2022.105758 PMC 바로가기 [Article Type] Article